In 2005 our pediatric congenital heart surgery program abandoned the Buckberg cardioplegia solution and adopted a modified depolarizing solution commonly referred to as del Nido cardioplegia. The developmental history and use of del Nido cardioplegia was recently described in the September 2012, Volume 44, Number 3 Guest Editorial of JECT ( 16 ).

Del Nido cardioplegia was initially used in pediatric patients and has been expanding into adult cardiac centers over the last decade. It can be used as a single dose and it is a reasonable tool do decrease cardioplegic interventions.

Warm induction followed by cold infusion prevented any agglutination and eliminated the need for subsequent cardioplegia doses. Following the cross-clamp period, the heart returned to normal sinus rhythm without need for defibrillation. Composition of del Nido and Blood Cardioplegia Solutions. Del Nido solution is composed of mixed blood and Plasma-Lyte A (1:4) (total volume: 1060 mL).

We randomized 100 pediatric patients aged ≤12 years undergoing elective repair of ventricular septal defects and tetralogy of Fallot to the DN and the STH groups. In the DN group, a 20 mL/kg single dose was administered. Objective: The del Nido cardioplegia solution provides a long period of arrest with single dose as compare to St. Thomas cardioplegia solution. In our study we compared outcomes of del Nido and St. Thomas cardioplegia in adult open cardiac surgeries. Methods: Sixty patients were studied between January 2017 to December 2017. Out of which 30 patients were operated on St. Thomas cardioplegia … Del Nido cardioplegia is routinely used in clinical practice both in paediatric and adult population in high volume centres.

2021-01-13 · DNC is a cold blood cardioplegia modified with a higher level of potassium. It was initially developed by Professor Pedro Del Nido at the University of Pittsburgh given the use in children's immature myocardium [ 3 ].

Cardioplegia Induction Plasmalyte / Tromethamine High Potassiu. Del Nido cardioplegia use in an adult, reoperative aortic valve population offers equivalent postoperative outcomes when compared with whole blood cardioplegia.

We are regional leaders in high complexity medical specialties, for adults and children, such as cardiovascular surgery, interventional cardiology, transplants,

Cardioplegia is an important strategy for myocardial protection during cardiac surgery. This meta-analysis was to compare the effects of del Nido and conventional cardioplegia in adult patients.

Additional prospective studies are needed to confirm these data. The del Nido cardioplegia is a crystalloid solution (Plasma-Lyte A, lidocaine, magnesium sulfate, potassium chloride, mannitol, sodium bicarbonate), mixed with blood in a 1:4 ratio (blood/crystalloid). Lidocaine is believed to be the primary component, as it increases the myocyte refractory period and reduces sodium and calcium influx.
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In 2005 our pediatric congenital heart surgery program abandoned the Buckberg cardioplegia solution and adopted a modified depolarizing solution commonly referred to as del Nido cardioplegia.

del Nido cardioplegia is a newer solution getting popular worldwide, whereas in Nepal, St. Thomas cardioplegia solution is conventionally used. There is no national recommendation on cardioplegia solutions supported by evidences from Nepalese studies. Conclusion: Del Nido cardioplegia is safe and can be used efficiently as an alternative to blood cardioplegia in isolated aortic valve replacement surgery.
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The del Nido. (dN) cardioplegia solution, the most commonly used cardioplegia, developed with some of the above- mentioned specific focus, is used by a third of

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Objectives: Del Nido cardioplegia (DNC) has been shown to be safe in adults with normal coronary arteries who are undergoing valve surgery. This study compared the effects of DNC versus traditional blood-based cardioplegia on postoperative complications in patients who underwent coronary artery bypass grafting (CABG).

All patients were operated by one surgeon (FJ).

11 Jun 2019 Del Nido cardioplegia is an extracellular solution mixed with autologous blood, the crystalloid: blood ratio is 4:1. Single dose of 20 ml/kg obtain

Cardioplegia solutions have been used for myocardial protection in cardiac surgery for decades. Different cardioplegic strategies have been evaluated. Del Nido cardioplegia was initially used in pediatric patients and has been expanding into adult cardiac centers over the last decade. Del Nido cardioplegia is routinely used in clinical practice both in paediatric and adult population in high volume centres. It could be a safe, effective and cheap myocardial protection strategy of universal implementation in cardiac surgery. Additional prospective studies are needed to confirm these data. The del Nido cardioplegia is a crystalloid solution (Plasma-Lyte A, lidocaine, magnesium sulfate, potassium chloride, mannitol, sodium bicarbonate), mixed with blood in a 1:4 ratio (blood/crystalloid).

2021-01-13 A novel formula for inducing cardioplegia was introduced in congenital heart surgery in 1995.5,6 Led by Pedro del Nido, MD, researchers from the University of Pittsburgh patented this formula as a single dose of a modiﬁed depolarizing solution. Commonly referred to as ‘‘del Nido … The del Nido cardioplegia is a crystalloid solution (Plasma-Lyte A, lidocaine, magnesium sulfate, potassium chloride, mannitol, sodium bicarbonate), mixed with blood in a 1:4 ratio (blood/crystalloid).